Comparison of evidence for linkage from different analytic methods

✍ Scribed by Shelley B. Bull; Dushanthi Pinnaduwage; Janey Shin; Fang Xie; David Tritchler

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 70 KB
• Volume: 14
• Category: Article
• ISSN: 0741-0395
• DOI: 10.1002/(sici)1098-2272(1997)14:6<965::aid-gepi67>3.0.co;2-j

✦ Synopsis

In a randomly chosen replicate of extended pedigrees from GAW10, we conducted robust multipoint genome scans for linkage using a dense marker map. For analysis of the quantitative traits, we selected sibships from the pedigrees, and for analysis of disease status, small families of affected relatives were selected. Lod-score likelihood analyses were conducted in the full pedigrees and in the affected relative families for selected regions. We located a flanking marker for MG1 on chromosome 5, and identified marker regions including MG2, MG4, and MG5 on chromosomes 8 and 9. The analytic methods were consistent for the major gene with a strong effect; false positive errors on chromosomes 1 and 10 could have been eliminated by requiring evidence from more than one method.