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Comparison of androgen receptor CAG and GGN repeat length polymorphism in humans and apes

✍ Scribed by Kyung-Won Hong; Emi Hibino; Osamu Takenaka; Ikuo Hayasaka; Yuichi Murayama; Shin’ichi Ito; Miho Inoue-Murayama


Publisher
Springer Japan
Year
2006
Tongue
English
Weight
385 KB
Volume
47
Category
Article
ISSN
0032-8332

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## Background: The androgen receptor (ar) gene has a polymorphic cag microsatellite encoding variable-length glutamine repeats in the ar protein. the purpose of this study was to evaluate the association between the growth of benign prostatic hyperplasia (bph) and the ar gene cag repeat length. ##

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The human androgen receptor (AR) gene possesses 2 trinucleotide repeats of CAG and GGN in exon 1. The CAG repeat corresponds to a polyglutamine tract in the N-terminal region of the receptor, that affects its transcriptional efficiency. The GGN repeat codifies for a polyglycine tract, and affects th