GGN repeat length and GGN/CAG haplotype variations in the androgen receptor gene and prostate cancer risk in south Indian men
β Scribed by Krishnaswamy Vijayalakshmi; Kumarasamy Thangaraj; Singh Rajender; Venkatesan Vettriselvi; Perumal Venkatesan; Sunil Shroff; K. N. Vishwanathan; Solomon F. D. Paul
- Publisher
- Nature Publishing Group
- Year
- 2006
- Tongue
- English
- Weight
- 170 KB
- Volume
- 51
- Category
- Article
- ISSN
- 1435-232X
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The human androgen receptor (AR) gene possesses 2 trinucleotide repeats of CAG and GGN in exon 1. The CAG repeat corresponds to a polyglutamine tract in the N-terminal region of the receptor, that affects its transcriptional efficiency. The GGN repeat codifies for a polyglycine tract, and affects th
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