## Abstract Changes in the length of a polymorphic trinucleotide (CAG) repeat in the androgen receptor (AR) gene, which may lead to altered transactivation of the AR gene, have been implicated to play a role in the pathogenesis of several forms of endocrine cancer and certain reproductive disorders
Codon-usage variants in the polymorphic (GGN)ntrinucleotide repeat of the human androgen receptor gene
β Scribed by Rose Lumbroso; Lenore K. Beitel; D. Marie Vasiliou; Mark A. Trifiro; L. Pinsky
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 47 KB
- Volume
- 101
- Category
- Article
- ISSN
- 0340-6717
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Uterine endometrial carcinoma is common among women. Several reports indicated that this cancer is influenced by androgens mediated through their receptors. The human androgen receptor gene contains a polymorphic CAG repeat in the coding region of exon 1. Other studies suggested a possible associati
Trinucleotide repeats are polymorphic in normal individuals. CAG repeats in the X-linked androgen receptor gene were counted by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI/TOF-MS). A region of approximately two hundred base-pairs containing the repeats was amp