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Comparison of aldose reductase inhibitors in vitro: Effects of enzyme purification and substrate type

✍ Scribed by Richard Poulsom


Book ID
115779431
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
591 KB
Volume
36
Category
Article
ISSN
0006-2952

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The stability and the hydrolysis kinetics of spirosuccinimide type aldose reductase (AR) inhibitors, SX-3030 (racemate) and its optical enantiomers (R- and S-isomers), were investigated in aqueous solution. The hydrolysis followed pseudo-first-order kinetics and showed significant pH dependence. Max