Approximate similarity and QSAR in the study of spirosuccinimide type aldose reductase inhibitors
✍ Scribed by Irene Luque Ruiz; Manuel Urbano-Cuadrado; Miguel Ángel Gómez-Nieto
- Book ID
- 106419470
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 262 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0259-9791
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The stability and the hydrolysis kinetics of spirosuccinimide type aldose reductase (AR) inhibitors, SX-3030 (racemate) and its optical enantiomers (R- and S-isomers), were investigated in aqueous solution. The hydrolysis followed pseudo-first-order kinetics and showed significant pH dependence. Max
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