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Long-term effect of an aldose reductase inhibitor on development of incipient nephropathy in type 2 diabetes mellitus

✍ Scribed by K Iso; H Tada; K Kuboki; Y Tojho; K Mogami; T Inokuchi

Book ID: 117369449
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 150 KB
Volume: 50
Category: Article
ISSN: 0168-8227
DOI: 10.1016/s0168-8227(00)80888-8

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The effect of two structurally unrelated aldose reductase inhibitors, sorbinil and ponalrestat, on glomerular prostaglandin production and urinary albumin excretion was investigated in rats with diabetes induced by streptozotocin. It was found that both aldose reductase inhibitors, when administered