Discovery of a New Cyclooxygenase-2 Lead Compound Through 3-D Database Searching and Combinatorial Chemistry. -A series of compounds (I) is prepared and screened for their antiinflammatory properties. The derivatives, bearing a gem-dimethyl group and aromatic ring substitution, such as (Id), exhibi
Comparison of 2D Similarity and 3D Superposition. Application to Searching a Conformational Drug Database.
β Scribed by Martin Thimm; Andrean Goede; Stefan Hougardy; Robert Preissner
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 7 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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