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ChemInform Abstract: Discovery of a New Cyclooxygenase-2 Lead Compound Through 3-D Database Searching and Combinatorial Chemistry.

✍ Scribed by K. D. STEWART; S. LOREN; L. FREY; E. OTIS; V. KLINGHOFER; K. I. HULKOWER

Publisher: John Wiley and Sons
Year: 2010
Weight: 29 KB
Volume: 29
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199822180

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✦ Synopsis

Discovery of a New Cyclooxygenase-2 Lead Compound Through 3-D Database Searching and Combinatorial Chemistry.

-A series of compounds (I) is prepared and screened for their antiinflammatory properties. The derivatives, bearing a gem-dimethyl group and aromatic ring substitution, such as (Id), exhibit enhanced activity. -(STEWART, K. D.; LOREN, S.;

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