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Comparative therapeutic effects of metformin and vitamin E in a model of non-alcoholic steatohepatitis in the young rat

โœ Scribed by Giuseppina Mattace Raso; Emanuela Esposito; Anna Iacono; Maria Pacilio; Salvatore Cuzzocrea; Roberto Berni Canani; Antonio Calignano; Rosaria Meli

Book ID
113588022
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
517 KB
Volume
604
Category
Article
ISSN
0014-2999

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## Summary **Background** :โ€‚Increased insulin resistance is the major pathogenic mechanism in the development of nonโ€alcoholic steatohepatitis. **Aim** :โ€‚To investigate the therapeutic effect of metformin, a wellโ€known insulinโ€sensitizing agent, in the treatment of nonโ€alcoholic steatohepatitis.