Comparative pharmacokinetics of coumarin anticoagulants V: Kinetics of warfarin elimination in the rat, dog, and rhesus monkey compared to man
โ Scribed by Renpei Nagashima; Gerhard Levy
- Publisher
- John Wiley and Sons
- Year
- 1969
- Tongue
- English
- Weight
- 524 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
d e n quantitation of small sulfamethazine peaks impractical. The chloroform wash of the basic aqueous mixture seems to affect this component m a t . Overwashing at this point, however, causes a loss of sulfamethazine. Homogenizing or grinding the tissue prior to extraction tends to improve recover
The anticoagulant warfarin exemplifies a type of drug that exhibits high affinity to pharmacologic target sites of limited capacity, resulting in unusual concentration-dependent distribution and elimination properties. The time course of warfarin concentrations in the serum, liver, kidneys, muscle,