A new sustained release dosage form of valproic acid (VPA) was developed. The new sustained release dosage form was administered (twice, with and without food) to five dogs in comparison to a standard tablet (Depakine, Labaz) and an i.v. preparation of the drug. Drug level monitoring in the plasma w
Comparative pharmacokinetic analysis of a novel sustained-release dosage form of theophylline in humans
โ Scribed by I. Raz; M. Bialer; K. Salame; H. Bar-On
- Book ID
- 104802972
- Publisher
- Springer
- Year
- 1984
- Tongue
- English
- Weight
- 287 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0031-6970
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๐ SIMILAR VOLUMES
A pharmacokinetic analysis of two sustained-release dosage forms of theophylline (Theo-Dur@ and Theotrim@) was carried out following single and multiple dose administrations of the two formulations in five healthy subjects. Despite the prolonged absorption after administration of the two sustained-r
1. Five new sustained-release dosage forms of valproic acid (VPA) were developed. 2. The new sustained-release formulations were administered to six healthy subjects for comparison with a standard tablet and an i.v. preparation of the drug. 3. Three of the formulations exhibited a more prolonged and