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Comparative mutagenic activity of epoxides derived from 1,3-butadiene

✍ Scribed by C. de Meester; M. Mercier; F. Poncelet


Book ID
113250377
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
56 KB
Volume
97
Category
Article
ISSN
0165-1161

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A five step synthesis of (d,l)-estrane d
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A spidamne 2. obtained in two steps from 1.3-butadiene (ca 50 Q). was metho~ycdonylated GHMDS I dimethykarbonate) and akylated wilh idobenzoc+butene (K2CO3 / acetone) to give 8. Heating of I3 kd to the esuane derivative 9 with 6 contnAled centers. The overall yield from I .3-butediene was ca. 32 46.