A five step synthesis of (d,l)-estrane derivatives from 1,3-butadiene

✍ Scribed by Pierre- Yves Michellys; Hélène Pellissier; Maurice Santelli

• Book ID: 104224996
• Publisher: Elsevier Science
• Year: 1993
• Tongue: French
• Weight: 234 KB
• Volume: 34
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)91966-x

✦ Synopsis

A spidamne 2. obtained in two steps from 1.3-butadiene (ca 50 Q). was metho~ycdonylated GHMDS I dimethykarbonate) and akylated wilh idobenzoc+butene (K2CO3 / acetone) to give 8. Heating of I3 kd to the esuane derivative 9 with 6 contnAled centers. The overall yield from I .3-butediene was ca. 32 46.