Comparative features of colorectal and gastric cancers with microsatellite instability in Chinese patients
โ Scribed by Yan-qin Huang; Ying Yuan; Wei-ting Ge; Han-guang Hu; Su-zhan Zhang; Shu Zheng
- Book ID
- 111842917
- Publisher
- SP Zhejiang University Press
- Year
- 2010
- Tongue
- English
- Weight
- 534 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1673-1581
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## Abstract African Americans (AAs) have a 1.5 times higher risk of colorectal carcinoma (CRC) than Caucasians. Gene silencing through CpG island hypermethylation has been associated with the genesis or progression of microsatellite instability (MSI) largely due to 1 target for hypermethylation bei
## BACKGROUND. Microsatellite instability (MI) has been reported in some sporadic colon tumors and in cases of hereditary nonpolyposis colorectal cancer (HNPCC). The criteria for HNPCC have not been fully defined, and clinical criteria are used to identify as many HNPCC patients as possible. To cl