## Abstract A new synthetic route to enantiopure (2__S__,4__R__)‐4‐hydroxypipecolic acid from commercial ethyl (3__S__)‐4‐chloro‐3‐hydroxybutanoate is reported. The synthesis is based on the Pd‐catalyzed methoxycarbonylation of a 4‐alkoxy‐substituted δ‐valerolactam‐derived vinyl triflate followed b
Comparative enzymology of (2S,4R)4-fluoroglutamine and (2S,4R)4-fluoroglutamate
✍ Scribed by Arthur J.L. Cooper; Boris F. Krasnikov; John T. Pinto; Hank F. Kung; Jianyong Li; Karl Ploessl
- Book ID
- 116345879
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 413 KB
- Volume
- 163
- Category
- Article
- ISSN
- 1096-4959
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A concise, multi-gram scale method for producing the bioactive and enantiomerically pure epimers, (2S,4R)-and (2S,4S)-glutamic acids, in a single synthetic scheme is described.
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