Comparative capillary electrophoretic and nuclear magnetic resonance studies of the chiral recognition of racemic metomidate with cyclodextrin hosts
β Scribed by Gabriele Endresz; Bezhan Chankvetadze; Dieter Bergenthal; Gottfried Blaschke
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 538 KB
- Volume
- 732
- Category
- Article
- ISSN
- 1873-3778
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Capillary electrophoretic enantioseparation of compounds containing vicinal diol groups have been investigated using different β€-cyclodextrin (CD) derivatives and borate as a background electrolyte. Both native β€-CD and several β€-CD derivatives are examined. Chiral recognition is attributed to both
## Abstract In the present study the migration order of the propranolol enantiomers with various native CDs and neutral and charged CD derivatives was examined in capillary electrophoresis (CE). The reversal of the enantiomer migration order was observed due to sulfation of Ξ²βCD on its primary hydr
Proton nuclear magnetic resonance spectroscopy showed that piroxicam sodium salt forms an inclusion complex with beta-cyclodextrin in aqueous solution. The 1:1 stoichiometry of the complex was determined by the continuous variation method. Significant nuclear Overhauser effects were observed between