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Capillary electrophoretic chiral resolution of vicinal diols by complexation with borate and cyclodextrin: Comparative studies on different cyclodextrin derivatives

✍ Scribed by Martin G. Schmid; Karin Wirnsberger; Thomas Jira; Antje Bunke; Gerald Gübitz

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 168 KB
Volume: 9
Category: Article
ISSN: 0899-0042
DOI: 10.1002/(sici)1520-636x(1997)9:2<153::aid-chir14>3.0.co;2-m

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✦ Synopsis

Capillary electrophoretic enantioseparation of compounds containing vicinal diol groups have been investigated using different ␤-cyclodextrin (CD) derivatives and borate as a background electrolyte. Both native ␤-CD and several ␤-CD derivatives are examined. Chiral recognition is attributed to both enantioselective inclusion of the analyte into the chiral cavity of the CD and complexation with borate. The influence of concentration of the chiral selector, pH, and organic modifiers on the resolution was studied. Four diols were baseline separated.