โ Scribed by Mark Roffman; Eugene Gould; Samuel Brewer; Helen Lau; Barry Sachais; Dr. Nina Dixon; Linda Kaczmarek; Anne Le Sher
No coin nor oath required. For personal study only.
As part of a double-blind multicenter trial comparing oxaprotiline with amitriptyline and placebo in 308 outpatients with moderate depression, objective (salivary flow) and subjective (dry mouth, blurred visionlvisual disorder, and constipation) determinants of anticholinergic activity were assessed. Both active treatments, but not placebo, induced approximately a 40% reduction in salivary flow after one week of treatment with 75 mgl day h.s. Whereas amitriptyline caused a further reduction (26%) in salivary flow by the end of the trial (week 5), no such reduction was noted with oxaprotiline. With regards to subjective complaints, more patients experienced dry mouth and blurred vision/visual
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## Abstract Tritium labelled amitriptyline (__1__) of high specific activity was prepared. The tritium was incorporated by catalysed isotope exchange into the precursor dibenzosuberone, which had been previously converted into a cyclic ketal, in order to protect the oxoโgroup against reduction. It