Communication - Solvent Isotope Effects and the Mechanism of Chymotrysin Action
β Scribed by Kresge, A. J.
- Book ID
- 126245691
- Publisher
- American Chemical Society
- Year
- 1973
- Tongue
- English
- Weight
- 417 KB
- Volume
- 95
- Category
- Article
- ISSN
- 0002-7863
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π SIMILAR VOLUMES
Adamantane and 1,3,5,7-tetradeuterioadamantane were oxidized by RuO, in two solvent systems, CCI,-CH,CN-H,O and acetone-water, yielding two kinetic deuterium isotope effects (KIEs), 4.8 f 0.2 and 7.8 i 0-1, respectively, very similar to those obtained in analogous reactions with cis-decalin and perd
## Abstract The basic principles and illustrative applications to enzyme mechanisms of solvent isotope effects, with emphasis on the use of rate measurements in mixtures of protium and deuterium oxides (βproton inventoriesβ), are reviewed over a period slightly shorter than the history of this Jour