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Common Polymorphisms in the MDM2 and TP53 Genes and the Relationship between TP53 Mutations and Patient Outcomes in Glioblastomas

✍ Scribed by Izabela Zawlik; Daisuke Kita; Salvatore Vaccarella; Michel Mittelbronn; Silvia Franceschi; Hiroko Ohgaki

Book ID
111404556
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
136 KB
Volume
19
Category
Article
ISSN
1015-6305

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We have investigated the mutation of the TP53 gene in hepatoblastomas (HBLs) by using polymerase chain reaction-single strand conformation polymorphism and direct sequencing in 38 HBL tumor samples and in two HBL cell lines. We detected the TP53 gene mutation in an anaplastic hepatoblastoma cell lin