Common fragile sites: mechanisms of instability revisited
✍ Scribed by Michelle Debatisse; Benoît Le Tallec; Anne Letessier; Bernard Dutrillaux; Olivier Brison
- Book ID
- 113933196
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 710 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0168-9525
No coin nor oath required. For personal study only.
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## Abstract Common chromosome fragile sites occur at specific sequences within mammalian genomes that exhibit apparent single‐stranded regions in mitotic chromosomes on exposure of cells to replication stress. Recent progress in the characterization of sequences, and more precise mapping of common
## Abstract Common fragile sites (CFSs) are loci that are especially prone to forming gaps and breaks on metaphase chromosomes under conditions of replication stress. Although much has been learned about the cellular responses to gaps and breaks at CFSs, less is known about what makes these sites i