Chromosomal Instability at Common Fragile Sites in Seckel Syndrome
β Scribed by Anne M. Casper; Sandra G. Durkin; Martin F. Arlt; Thomas W. Glover
- Book ID
- 117854478
- Publisher
- American Society of Human Genetics
- Year
- 2004
- Tongue
- English
- Weight
- 330 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0002-9297
- DOI
- 10.1086/422701
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## Abstract Common fragile sites (CFSs) are loci that are especially prone to forming gaps and breaks on metaphase chromosomes under conditions of replication stress. Although much has been learned about the cellular responses to gaps and breaks at CFSs, less is known about what makes these sites i
## Abstract Common chromosome fragile sites occur at specific sequences within mammalian genomes that exhibit apparent singleβstranded regions in mitotic chromosomes on exposure of cells to replication stress. Recent progress in the characterization of sequences, and more precise mapping of common