Comments on the origin of platelet deposition1 and on cell adhesion to biomaterial surfaces2

✍ Scribed by Neumann, A. W. ;Francis, D. W. ;Zingg, W. ;van Oss, C. J. ;Absolom, D. R.

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 485 KB
• Volume: 17
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/jbm.820170213

✦ Synopsis

In a recent issue of this journal, Ruckenstein and Srinivasanl criticized a paper we published in 1980 dealing with platelet adhesion to polymeric substrates. In the same issue, R. E. Baier' published a guest editorial, apparently meant asa comment to our debate with Ruckenstein and Srinivasan, which, however, failed to focus on the clear-cut question being debated. Both publications require comment.

REBUTTAL T O RUCKENSTEIN A N D SRINIVASAN'

The strategy of Ruckenstein's critique of our work is sufficiently unusual to require a restatement of the facts. In our publication of 1980,j we reported data on the kinetics of platelet adhesion from suspension to various surfaces, all polymeric in nature except glass. In that publication, we compared our results with the theory of Ruckenstein, Marmur, and Rakowefl published in 1976. We pointed out that although we could not see any inherent flaws in their assumptions nor in the development of their theory, our experimental results were at variance with their predictions. In response to our p ~b l i c a t i o n , ~ Srinivasan and Ruckenstein5 published a paper in which they modified their initial theory? apparently to make their theoretical prediction conform to experimental results such as ours. While this is of course acceptable, we find it surprising that in 1982 Ruckenstein and Srinivasanl wrote a rebuttal to our 1980 article, on the basis of their 19815 study. To clarify: The PIP dictions of Ruckenstein et al.4 in their 1976 article are grossly at variance with our experimental observations, and Ruckenstein and Srinivasan,' while not at all lucid on the description of the historical sequence of events, do not challenge the findings of our 1980