𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effect of fibronectin on the adhesion of an established cell line to a surface reactive biomaterial

✍ Scribed by Seitz, T. L. ;Noonan, K. D. ;Hench, L. L. ;Noonan, N. E.

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
855 KB
Volume
16
Category
Article
ISSN
0021-9304

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

We have demonstrated that an established hamster cell line (NIL 8 M‐2) will adhere to the bioceramic bioglass. The rate at which the NIL 8 M‐2 cells assume a spread morphology on bioglass is density dependent and the morphology displayed by NIL 8 M‐2 cells attached to bioglass is much more elongated than that displayed by NIL 8 M‐2 cells attached to nonreactive glass. Precoating the bioglass with the plasma form of human fibronectin significantly reduces the density dependent nature of cell spreading. Coating the bioglass with fibronectin also reduces the time required for cell spreading and changes the morphology of the attached cells from an elongated to an extremely flattened shape. Our work raises the possibility that bone‐implant adhesion might be improved by introducing molecules relevant to cell‐substrate attachment into the biomaterial prior to implantation.

πŸ“œ SIMILAR VOLUMES

Effect of surface reaction stage on fibr
Effect of surface reaction stage on fibronectin-mediated adhesion of osteoblast-like cells to bioactive glass
✍ GarcοΏ½a, AndrοΏ½s J. ;Ducheyne, Paul ;Boettiger, David πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 154 KB πŸ‘ 2 views

Bioactive glasses and ceramics enhance bone formation and bond directly to bone, and have emerged as promising substrates for bone tissue engineering applications. Bone bioactivity involves physicochemical surface reactions and cellular events, including cell attachment to adsorbed extracellular mat

Comments on the origin of platelet depos
Comments on the origin of platelet deposition1 and on cell adhesion to biomaterial surfaces2
✍ Neumann, A. W. ;Francis, D. W. ;Zingg, W. ;van Oss, C. J. ;Absolom, D. R. πŸ“‚ Article πŸ“… 1983 πŸ› John Wiley and Sons 🌐 English βš– 485 KB

In a recent issue of this journal, Ruckenstein and Srinivasanl criticized a paper we published in 1980 dealing with platelet adhesion to polymeric substrates. In the same issue, R. E. Baier' published a guest editorial, apparently meant asa comment to our debate with Ruckenstein and Srinivasan, whic

Removal of surface by-products from sint
Removal of surface by-products from sintered hydroxyapatite: Effect of a chelation treatment on fibronectin adsorption and cell adhesion
✍ Delphine Pellenc; SΓ©bastien Giraudier; Eric Champion; Karine Anselme; VΓ©ronique πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 235 KB πŸ‘ 1 views

## Abstract It was observed that fibronectin precipitates when deposited on hydroxyapatite (HA) ceramics. Fibronectin's known affinity for calcium and the composition of the ceramic itself suggested that calcium release could be the main cause of this aggregation effect. It was then decided to inve

Effect of fibronectin amount and conform
Effect of fibronectin amount and conformation on the strength of endothelial cell adhesion to HEMA/EMA copolymers
✍ Burmeister, J. S. ;Vrany, J. D. ;Reichert, W. M. ;Truskey, G. A. πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 912 KB

The effect of substrate surface hydrophobicity on fibronectin (Fn) adsorption and endothelial cell adhesion strength was studied. Bovine aortic endothelial cells (BAEC) were plated for 2 h with and without preadsorbed Fn on slides coated with homopolymers and copolymers of hydrophilic polyhydroxyeth