✦ LIBER ✦

Combining mortality and longitudinal measures in clinical trials

✍ Scribed by Dianne M. Finkelstein; David A. Schoenfeld

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 117 KB
Volume: 18
Category: Article
ISSN: 0277-6715
DOI: 10.1002/(sici)1097-0258(19990615)18:11<1341::aid-sim129>3.0.co;2-7

No coin nor oath required. For personal study only.

✦ Synopsis

Clinical trials often assess therapeutic beneÿt on the basis of an event such as death or the diagnosis of disease. Usually, there are several additional longitudinal measures of clinical status which are collected to be used in the treatment comparison. This paper proposes a simple non-parametric test which combines a time to event measure and a longitudinal measure so that a substantial treatment di erence on either of the measures will reject the null hypothesis. The test is applied on AIDS prophylaxis and paediatric trials.

📜 SIMILAR VOLUMES

Longitudinal data analysis (repeated mea

Longitudinal data analysis (repeated measures) in clinical trials

✍ Paul S. Albert 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 227 KB 👁 2 views

Longitudinal data is often collected in clinical trials to examine the e!ect of treatment on the disease process over time. This paper reviews and summarizes much of the methodological research on longitudinal data analysis from the perspective of clinical trials. We discuss methodology for analysin

Outcome measures for clinical trials in

Outcome measures for clinical trials in multiple sclerosis

✍ Hillel S. Panitch 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 136 KB 👁 1 views

Repeated measures in clinical trials: si

Repeated measures in clinical trials: simple strategies for analysis using summary measures

✍ Stephen Senn; Lynda Stevens; Nish Chaturvedi 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 142 KB 👁 2 views

The summary measures approach to analysing repeated measures is described. The circumstances under which it can be advantageous to use such measures are considered. Strategies for baseline adjustment where there are multiple baselines are examined, as is the choice of appropriate summary statistic.

Combining the Pragmatic Attitude and the

Combining the Pragmatic Attitude and the Play-the-Winner in Controlled Clinical Trials

✍ J. Jamart 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 259 KB

Attitudes in clinical trials

✍ Peter Armitage 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 74 KB 👁 1 views

Two important papers by Schwartz and Lellouch have drawn distinctions between explanatory and pragmatic attitudes to clinical trials, and between individual and collective ethics. The pragmatic approach accords with the widespread use of 'intention-to-treat' analyses, but recent research has started

Clinical trials in neurology

✍ Karl D. Kieburtz 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 42 KB 👁 2 views