✦ LIBER ✦

Attitudes in clinical trials

✍ Scribed by Peter Armitage

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 74 KB
Volume: 17
Category: Article
ISSN: 0277-6715
DOI: 10.1002/(sici)1097-0258(19981215)17:23<2675::aid-sim34>3.0.co;2-1

No coin nor oath required. For personal study only.

✦ Synopsis

Two important papers by Schwartz and Lellouch have drawn distinctions between explanatory and pragmatic attitudes to clinical trials, and between individual and collective ethics. The pragmatic approach accords with the widespread use of 'intention-to-treat' analyses, but recent research has started to explore models for non-compliance adjustment which seek an explanatory approach. Individual and collective ethics often co-exist, and standard approaches to randomization may provide the most satisfactory compromise.

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