✦ LIBER ✦

Combined vascular targeted imaging and therapy: A paradigm for personalized treatment

✍ Scribed by King C.P. Li; Samira Guccione; Mark D. Bednarski

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 236 KB
Volume: 87
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.10401

No coin nor oath required. For personal study only.

✦ Synopsis

In order to be successful in personalizing treatment, methods for selecting patients as well as good surrogate biomarkers for monitoring the effects of treatment are required in addition to development of an efficacious targeted therapy. We have developed a polymerized nanoparticle platform technology that will allow us to put different targeting moieties on the surface of the particles in addition to loading the particles with different contrast and therapeutic agents. We have proven that these nanoparticles can be targeted to endothelial receptors and different payloads of contrast and therapeutic agents have been delivered to target cells with high target to background ratios. Using this combined vascular targeted imaging and therapy approach, we are optimistic that personalized treatment regimens can be developed for different disease processes such as cancer, inflammation, and ischemia.

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