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Combined effect of genetic polymorphisms in phase I and II biotransformation enzymes on head and neck cancer risk

✍ Scribed by Martin Lacko; Adri C. Voogd; Hennie M. J. Roelofs; Rene H. M. te Morsche; Michel B. Oude Ophuis; Wilbert H. M. Peters; Johannes J. Manni

Book ID
112097779
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
209 KB
Volume
35
Category
Article
ISSN
1043-3074

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## Abstract UDP‐glucuronosyltransferase 1A1 (UGT1A1) is an enzyme which catalyses not only the glucuronidation of tobacco smoke carcinogens like benzopyrene, but also of the endogenous substrate bilirubin. Bilirubin for a long time was considered to be only a toxic waste product of hemoglobin degra