Combined 5-fluorouracil and floxuridine administered as a 14-day infusion. A phase I study
โ Scribed by Norwood Anderson; Jacob Lokich; Murray Bern; Sabina Wallach; Cherie Moore; David Williams; Vimonrat Umprayn
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 301 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0008-543X
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๐ SIMILAR VOLUMES
## BACKGROUND. This study was designed to assess the toxicity of pelvic radiation therapy, 5-fluorouracil (5-FU) administered by protracted venous infusion, and leucovorin. ## METHODS. Pelvic radiation therapy consisted of 50.4 -54 gray (Gy) administered in 28 -30 fractions. Systemic treatment
Two consecutive Phase I trials of continuous infusion 5-fluorouracil (5-FU) or floxuridine (5-FUdR) admixed with leucovorin (LCV) were performed and involved 19 and 24 patients, respectively. The studies were carried out to identify the optimal dose rate of delivery for the two admixtures (5-FU + LC