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Phase I study of 5-fluorouracil administered by protracted venous infusion, leucovorin, and pelvic radiation therapy

โœ Scribed by James A. Martenson; Thomas G. Shanahan; Michael J. O'Connell; Charles D. Cobau; Georgene Schroeder; Patrick A. Burch; Ralph Levitt; Kendrith M. Rowland Jr.

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
63 KB
Volume
86
Category
Article
ISSN
0008-543X

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โœฆ Synopsis

BACKGROUND.

This study was designed to assess the toxicity of pelvic radiation therapy, 5-fluorouracil (5-FU) administered by protracted venous infusion, and leucovorin.

METHODS.

Pelvic radiation therapy consisted of 50.4 -54 gray (Gy) administered in 28 -30 fractions. Systemic treatment consisted of leucovorin (10 mg daily) administered orally and protracted venous infusion of 5-FU. The initial daily 5-FU dose was 150 mg/m 2 . Dose escalations were planned in increments of 25 mg/m 2 .

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## BACKGROUND. The aim of this study was to define the maximum tolerated doses