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Continuous infusion 5-fluorouracil with escalating doses of intermittent cisplatin and etoposide. A phase I study

✍ Scribed by Thomas Saphner; Douglass C. Tormey; Mark Albertini


Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
401 KB
Volume
68
Category
Article
ISSN
0008-543X

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A phase II trial of weekly high dose con
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Background. In a previous Phase I1 trial, the authors showed that a weekly continuous infusion of 5-fluorouracil (5-FU) at a dose of 3.5 g/mz for 48 hours is an active treatment for advanced colorectal cancer. The overall response rate was 38.5%, and the median survival was 12 months. These data wer