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Combination therapy of Ad-mda7 and trastuzumab increases cell death in Her-2/neu–overexpressing breast cancer cells

✍ Scribed by Tamra McKenzie; Yanna Liu; Michelle Fanale; Stephen G. Swisher; Sunil Chada; Kelly K. Hunt

Book ID: 113919828
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 223 KB
Volume: 136
Category: Article
ISSN: 0039-6060
DOI: 10.1016/j.surg.2004.05.022

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Human epidermal growth factor receptor 2 (HER2) is frequently overexpressed in human breast cancers. It is known to drive tumor growth and progression and represents a prominent target in breast cancer therapy. The endothelin (ET) system, in particular ET-1 and its receptor ET A R, is of major relev