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Phosphorylated HER-2 tyrosine kinase and Her-2/neu gene amplification as predictive factors of response to trastuzumab in patients with HER-2 overexpressing metastatic breast cancer (MBC)

✍ Scribed by Rosa Giuliani; Virginie Durbecq; Angelo Di Leo; Marianne Paesmans; Denis Larsimont; Jean-Yves Leroy; Marleen Borms; Anita Vindevoghel; Guy Jerusalem; Veronique D’Hondt; Luc Dirix; Jean-Luc Canon; Vincent Richard; Veronique Cocquyt; Françoise Majois; Michel Reginster; Jan Demol; Jean-Pierre Kains; Paul Delree; Carine Keppens; Christos Sotiriou; Martine J. Piccart; Fatima Cardoso


Book ID
116429234
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
636 KB
Volume
43
Category
Article
ISSN
0959-8049

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## Abstract Her‐2/__neu__ overexpression in human breast cancer leads to an aggressive biological behavior and poor prognosis. Although the anti‐Her‐2/__neu__ antibody trastuzumab (Herceptin®) has become a valuable therapeutic option for patients with Her‐2/__neu__‐overexpressing breast cancer, man