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Increased cell size and Akt activation in HER-2/neu-overexpressing invasive ductal carcinoma of the breast

✍ Scribed by X Sastre-Garau; P Genin; A Rousseau; A Al Ghuzlan; A Nicolas; P Fréneaux; C Rosty; B Sigal-Zafrani; J Couturier; J-P Thiery; H Magdelénat; A Vincent-Salomon


Book ID
108779691
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
497 KB
Volume
45
Category
Article
ISSN
0309-0167

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Human epidermal growth factor receptor 2 (HER2) is frequently overexpressed in human breast cancers. It is known to drive tumor growth and progression and represents a prominent target in breast cancer therapy. The endothelin (ET) system, in particular ET-1 and its receptor ET A R, is of major relev