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Combination cytokine therapy inhibits tumor growth by generation of tumor-specific T-cell responses in a murine melanoma model

✍ Scribed by Amer N. Kalaaji; Jun Lu; Svetomir N. Markovic; Esteban Celis; Mark R. Pittelkow


Book ID
116399391
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
505 KB
Volume
49
Category
Article
ISSN
1043-4666

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Melanoma-specific T-cells (CTLs) are specifically cytotoxic for autologous tumor, when assayed in vitro. To examine their effectiveness in vivo, we tested the ability of these human T-cells to inhibit growth of human melanoma xenografts by using a Winn assay. Nude mice receiving specific CTLs (n = 1