Column extraction method for rapid preparation of [11C]acetic and [11C]palmitic acids
β Scribed by Ren Iwata; Tatsuo Ido; Masao Tada
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 406 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0969-8043
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A semi-automated synthesis of [1-"Clacetate for routine clinical studies by positron emission tomography is described. Carboxylation of methylmagnesium chloride in THF with ["C]CO, followed by the HCl hydrolysis at low temperature gave [I-"Clacetic acid, which was distilled with a N, flow into a NaH
## Abstract An example of a potentially general method for the preparation of ^14^Cβcarboxylic acids based on the carbonation of an Ξ±βlithiated carboxylate is described. This procedure requires only the unlabeled analog of the desired ^14^Cβacid as the precursor. The possibility of carrying out the