A distillation method of preparing C-11 labeled acetate for routine clinical use

✍ Scribed by Kiichi Ishiwata; Shin-Ichi Ishii; Toru Sasaki; Michio Senda; Tadashi Nozaki

• Publisher: Elsevier Science
• Year: 1993
• Tongue: English
• Weight: 251 KB
• Volume: 44
• Category: Article
• ISSN: 0969-8043
• DOI: 10.1016/0969-8043(93)90145-z

✦ Synopsis

A semi-automated synthesis of [1-"Clacetate for routine clinical studies by positron emission tomography is described. Carboxylation of methylmagnesium chloride in THF with ["C]CO, followed by the HCl hydrolysis at low temperature gave [I-"Clacetic acid, which was distilled with a N, flow into a NaHCO, solution. After radioactive and nonradioactive undesirable products were removed by evaporation of the solution to dryness, a sterile and apyrogenic [I-"Clacetate injection was obtained within 20 min.