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Colonic effects of TAK-637: A novel NK, receptor antagonist

✍ Scribed by Venkova, Kalina; Tyler, Karl; Sutkowski-Markmann, Debra

Book ID
124130639
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
194 KB
Volume
120
Category
Article
ISSN
0016-5085

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Microbial synthesis of a deuterium-label
Microbial synthesis of a deuterium-labelled metabolite of an NK1 receptor antagonist, TAK-637
✍ Naoki Tarui; Yoshinori Ikeura; Hideaki Natsugari; Kazuo Nakahama πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 French βš– 95 KB

## Abstract Microbial conversion of deuterium‐labelled TAK‐637 ((__aR,9S__)‐[10,10,11, 11‐^2^H~4~]‐7‐[3,5‐__bis__(trifluoromethyl)benzyl]‐8,9,10,11‐tetrahydro‐9‐methyl‐5‐(4‐methylphenyl)‐__7H__‐[1,4]diazocino[2,1‐__g__][1,7]naphthyridine‐6,13‐dione, **1**) was carried out using __Streptomyces subru