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Coffee diterpenes prevent the genotoxic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and N-nitrosodimethylamine in a human derived liver cell line (HepG2)

✍ Scribed by B.J. Majer; E. Hofer; C. Cavin; E. Lhoste; M. Uhl; H.R. Glatt; W. Meinl; S. Knasmüller


Book ID
116461357
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
208 KB
Volume
43
Category
Article
ISSN
0278-6915

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2-amino-1-methyl-6-phenylimidazo [4,5-b]
✍ Kristin J. Metry; Shuang Zhao; Jason R. Neale; Mark A. Doll; J. Christopher Stat 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 188 KB

## Abstract Heterocyclic amine carcinogens such as 2‐amino‐1‐methyl‐6‐phenylimidazo [4,5‐b] pyridine (PhIP) are present in diet and cigarette smoke. Bioactivation in humans includes N‐hydroxylation catalyzed by cytochrome P4501A2 possibly followed by O‐acetylation catalyzed by N‐acetyltransferase 2