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Cytogenetic effects of a food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), and its metabolite, 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP), on human and Chinese hamster cells in vitro

✍ Scribed by Chino Otsuka; Kunihiko F. Miura; Takatomo Satoh; Midori Hatanaka; Keiji Wakabayashi; Motoi Ishidate Jr.


Book ID
116098486
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
433 KB
Volume
367
Category
Article
ISSN
0165-1218

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## 2-Amino -1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the most abundant heterocyclic aromatic amine found in cooked meat. It is metabolically activated by the human cytochrome P450 enzymes to form the carcinogenic metabolite N 2 -OH-PhIP. PhIP has been found to induce tumors in rats and is