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DNA adducts formed by the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in vitro and in vivo. Identification of a PhIP-2-deoxyguanosine adduct

✍ Scribed by H. Frandsen; S. Grivas; L. Dragsted; J.C. Larsen


Book ID
113252488
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
87 KB
Volume
271
Category
Article
ISSN
0165-1161

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## Abstract 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐__b__]pyridine (PhIP) is the most abundant heterocyclic amine derived from food, possibly involved in human carcinogenesis. We evaluated the formation of PhIP‐DNA adducts in lymphocytes from 76 incident colorectal cancer patients likely to be exposed