Cocaine-induced midline destructive lesions — An autoimmune disease?
✍ Scribed by Trimarchi, M.; Bussi, M.; Sinico, R.A.; Meroni, Pierluigi; Specks, U.
- Book ID
- 122907683
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 480 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1568-9972
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📜 SIMILAR VOLUMES
## Abstract ## Objective Antineutrophil cytoplasmic antibodies (ANCA) binding to neutrophil elastase (NE) and proteinase 3 (PR3) are detectable in most patients with cocaine‐induced midline destructive lesions (CIMDL), but the pathogenic role and antigen specificity of these antibodies are unknown
## Abstract ## Objective Human neutrophil elastase (HNE) and proteinase 3 (PR3) are structurally and functionally related. PR3 is the prominent target antigen for antineutrophil cytoplasmic antibodies (ANCAs) in Wegener's granulomatosis (WG). Reported frequencies of HNE ANCAs in WG and other autoi