Cocaine-induced midline destructive lesion
β Scribed by C. Angit; M. T. Dabrowski; C. M. Owen
- Book ID
- 108695431
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 246 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0307-6938
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π SIMILAR VOLUMES
## Abstract ## Objective Antineutrophil cytoplasmic antibodies (ANCA) binding to neutrophil elastase (NE) and proteinase 3 (PR3) are detectable in most patients with cocaineβinduced midline destructive lesions (CIMDL), but the pathogenic role and antigen specificity of these antibodies are unknown
## Abstract ## Objective Human neutrophil elastase (HNE) and proteinase 3 (PR3) are structurally and functionally related. PR3 is the prominent target antigen for antineutrophil cytoplasmic antibodies (ANCAs) in Wegener's granulomatosis (WG). Reported frequencies of HNE ANCAs in WG and other autoi