P.247 Cocaine-induced pseudovasculitis and midline destructive lesions. Differencial diagnosis and report
β Scribed by S. Sanchez Santolino; M.F. Garcia Reija; B. Garcia Montesinos; R. Saiz Bustillo
- Book ID
- 119581184
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 62 KB
- Volume
- 34
- Category
- Article
- ISSN
- 1010-5182
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π SIMILAR VOLUMES
## Abstract ## Objective Antineutrophil cytoplasmic antibodies (ANCA) binding to neutrophil elastase (NE) and proteinase 3 (PR3) are detectable in most patients with cocaineβinduced midline destructive lesions (CIMDL), but the pathogenic role and antigen specificity of these antibodies are unknown
## Abstract ## Objective Human neutrophil elastase (HNE) and proteinase 3 (PR3) are structurally and functionally related. PR3 is the prominent target antigen for antineutrophil cytoplasmic antibodies (ANCAs) in Wegener's granulomatosis (WG). Reported frequencies of HNE ANCAs in WG and other autoi