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CO2 laser resurfacing and photocarcinogenesis: An experimental study

✍ Scribed by Lene Hedelund; Merete Haedersdal; Henrik Egekvist; Michael Heidenheim; Hans Christian Wulf; Thomas Poulsen

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 55 KB
Volume: 35
Category: Article
ISSN: 0196-8092
DOI: 10.1002/lsm.20067

No coin nor oath required. For personal study only.

✦ Synopsis

Background and Objectives: To examine whether carbon dioxide (CO 2 ) laser treatment has a carcinogenic potential or may influence ultraviolet (UV)-induced carcinogenesis. Study Design/Materials and Methods: Hairless mice (n ¼ 211) were treated with a Sharplan CO 2 laser with FeatherTouch scanner. Simulated solar irradiations were administrated either pre-operatively or pre-and postoperatively. Weekly clinical assessments of skin tumors were performed blinded during the entire observation period of 12 months. Results: No tumors appeared (a) in mice just treated with CO 2 laser, (b) in mice exposed to UV irradiation only before CO 2 laser treatment or (c) in untreated control mice. Tumors developed in CO 2 laser treated mice that were exposed to UV-irradiation both pre-and post-operatively and in UV-irradiated control mice. The time to first, second, and third tumors ranged from 18 to 20 weeks and no significant differences were demonstrated. Conclusions: CO 2 laser treatment does not have a carcinogenic potential in itself, nor does CO 2 laser treatment influence UV-induced carcinogenesis. Lasers Surg.

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