𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Experimental model for the long-term effects of laser resurfacing

✍ Scribed by Srdan Babovic; Melanie Triffet Trevino; Paul M. Petty

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
141 KB
Volume
28
Category
Article
ISSN
0196-8092

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background and Objective

Evaluation of the long‐term effects of the laser resurfacing on development of the skin cancer after chronic ultraviolet B light exposure calls for the development of the appropriate animal model.

Study Design/Materials and Methods

The 27 C3H nu/nu nude mice were used in the experiment. Five experimental groups were designed to evaluate the effects of laser energy delivered.

Results

Tru‐Pulse^™^ Laser System produced char‐free crust immediately after application. There was no histologic difference in laser effects on the skin between groups. Complete re‐epithelialization occurred within 7 days.

Conclusions

An entire lifetime in this mammal model can be studied in under 2.5 years. The back skin of the mice can be resurfaced by using one pass 500 mJ/cm^2^ and complete healing will occur within a 7‐day period. We believe that establishment of this experimental model has set the stage for the further study of the effect of laser energy on sun‐damaged skin. Carbon dioxide laser resurfacing has become an increasingly popular method of facial rejuvenation, allowing the plastic surgeon to repair sun‐damaged skin and wrinkles. Results obtained by laser resurfacing seem to be long lasting. Carbon dioxide laser resurfacing brings about histologic changes in the skin. This finding raises a new question: Does carbon dioxide laser skin resurfacing modulate the effects of ultraviolet (UV) light exposure on the skin? The purpose of this study was to establish a new experimental model for studying the long‐term effects of laser skin resurfacing. Lasers Surg. Med. 28:138–140, 2001. © 2001 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Modelling the long-term cost-effectivene
Modelling the long-term cost-effectiveness of endovascular or open repair for abdominal aortic aneurysm
✍ D. M. Epstein; M. J. Sculpher; A. Manca; J. Michaels; S. G. Thompson; L. C. Brow 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 129 KB 👁 2 views

## Abstract ## Background Recent randomized trials have shown that endovascular abdominal aortic aneurysm repair (EVAR) has a 3 per cent aneurysm-related survival benefit in patients fit for open surgery, but it also has uncertain long-term outcomes and higher costs. This study assessed the cost-e

A clinical comparison and long-term foll
A clinical comparison and long-term follow-up of topical 5-fluorouracil versus laser resurfacing in the treatment of widespread actinic keratoses
✍ Judith U. Ostertag; Patricia J.F. Quaedvlieg; Simone van der Geer; Patty Neleman 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 253 KB

## Abstract ## Background and Objectives: Many treatment modalities exist for actinic keratoses (AK). Topical 5‐fluorouracil (5‐FU) has been one of the standard treatments. Laser resurfacing is a more recent treatment option. In the literature prospective randomized studies comparing these treatme

Murine model of prosthesis failure for t
Murine model of prosthesis failure for the long-term study of aseptic loosening
✍ Shang-You Yang; Haiying Yu; Weiming Gong; Bin Wu; Lois Mayton; Richard Costello; 📂 Article 📅 2007 🏛 Elsevier Science 🌐 English ⚖ 443 KB

## Abstract We examined a novel mouse model of wear debris‐induced prosthesis instability and osteolysis, and its application for the evaluation of therapy. A stainless steel or titanium‐alloy pin was implanted into the proximal tibia to form a contiguous surface with the articular cartilage. In so

The Effect of Estimating Parameters on L
The Effect of Estimating Parameters on Long-Term Forecasts for Cointegrated Systems
✍ Hiroaki Chigira; Taku Yamamoto 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 412 KB

## ABSTRACT This paper concerns Long‐term forecasts for cointegrated processes. First, it considers the case where the parameters of the model are known. The paper analytically shows that neither cointegration nor integration constraint matters in Long‐term forecasts. It is an alternative implicati

Modelling the effects of trade-offs betw
Modelling the effects of trade-offs between long and short-term objectives in fisheries management
✍ Simon Mardle; Sean Pascoe 📂 Article 📅 2002 🏛 Elsevier Science 🌐 English ⚖ 169 KB

Fisheries management is typically a complex problem, from both an environmental and political perspective. The main source of conflict occurs between the need for stock conservation and the need for fishing community well-being, which is typically measured by employment and income levels. For most f