CO2 laser-resurfacing: Increased risk of side effects after uv-exposure—an experimental animal study
✍ Scribed by Lene Hedelund; Merete Haedersdal; Henrik Egekvist; Michael Heidenheim; Christian Wulf Hans; Thomas Poulsen
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 74 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0196-8092
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Background and Objectives
Carbon dioxide (CO~2~) laser resurfacing is primarily performed on photodamaged facial skin where patients are further exposed to ultraviolet radiation (UVR) postoperatively. We examined whether pre‐ and postoperative UVR influences the development of CO~2~ laser‐induced side effects.
Study Design/Materials and Methods
Hairless mice (n = 211) were treated with a Sharplan CO~2~ laser with FeatherTouch scanner. Simulated solar irradiation was administered either preoperatively or pre‐ and postoperatively. Skin end‐points (wounds, texture changes, and pigmentary changes) were evaluated blinded by clinical evaluations, skin reflectance spectroscopy, and histological examinations.
Results
Pre‐ and postoperative UVR exposed mice obtained higher clinical scores of wounds (P < 0.02) and texture changes (P < 0.01) and developed more heavy fibrosis than mice treated with laser but no UVR. UVR exposure after CO~2~ laser treatment induced significant hyperpigmentation compared to unexposed control mice (P < 0.003), whereas CO~2~ laser treatment itself did not induce pigmentary changes.
Conclusions
UVR increases in an animal model the occurrence of postoperative side effects from CO~2~ laser resurfacing. Lasers Surg. Med. 36:79–84, 2005. © 2005 Wiley‐Liss, Inc.