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Co-inhibition of epidermal growth factor receptor and type 1 insulin-like growth factor receptor synergistically sensitizes human malignant glioma cells to CD95L-induced apoptosis

โœ Scribed by Joachim P. Steinbach; Christine Eisenmann; Andrea Klumpp; Michael Weller


Book ID
116288901
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
426 KB
Volume
321
Category
Article
ISSN
0006-291X

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## Abstract The type 1 insulin-like growth factor receptor (IGF-1R), which is over-expressed or activated in many human cancers, including lung cancer, mediates cancer cell proliferation and metastasis. Several studies indicate that blocking IGF-1R expression can inhibit tumor cell proliferation an