Type-1 insulin-like growth factor receptor reexpression in the malignant phenotype of SV40-T-immortalized human prostate epithelial cells enhances apoptosis

ASPB10 insulin induction of increased mi

ASPB10 insulin induction of increased mitogenic responses and phenotypic changes in human breast epithelial cells: Evidence for enhanced interactions with the insulin-like growth factor-I receptor

✍ Giovanni Milazzo; Laura Sciacca; Vincenzo Papa; Ira D. Goldfine; Riccardo Vigner 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 128 KB 👁 2 views

The human insulin analogue ASPB 10 has been reported to have increased affinity for the insulin receptor and to cause breast cancer in female rats. In the study reported here, we investigated whether ASPB 10 has an increased mitogenic potency and induces a transformed phenotype in cultured human bre